Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chloro-2,5-dimethoxyaniline → N2-(4-chloro-2,5-dimethoxyphenyl)-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chloro-2,5-dimethoxyaniline | HCID 22833 | — |
| 반응물 | 2-chloro-5-fluoro-N-(3-hydroxyphenyl)-4-pyrimidineamine | HCID 22060451 | — |
| 생성물 | N2-(4-chloro-2,5-dimethoxyphenyl)-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamine | HCID 22060583 | — |
반응 단계
In like manner to the preparation of N4-(3-chloro-4-trifluoromethoxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidineamine, the reaction of 2-chloro-5-fluoro-N4-(3-hydroxyphenyl)-4-pyrimidineamine with 4-chloro-2,5-dimethoxyaniline gave N2-(4-chloro-2,5-dimethoxyphenyl)-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamine. 1H NMR (CD3OD): δ 8.04 (d, 1H, J=5.4 Hz), 7.46 (s, 1H), 7.17 (m, 2H), 7.03 (m, 2H), 6.72 (dd, 1H, J=1.8 and 7.8 Hz), 3.85 (s, 3H), 3.52 (s, 3H); LCMS: purity: 98%; MS (m/e): 390 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07906644B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-1ef2ba62e38e49ea9b3bb5ff4e216990 |
| 출처 메모 | uspto-grants-2011_03 |