Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(1-Bromoethyl)benzene → (2R)-2-[{2-Amino-5-[(1-phenylethyl)thio][1,3]thiazolo[4,5-d]pyrimidin-7-yl}(methyl)amino]-4-methylpentan-1-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (1-Bromoethyl)benzene | HCID 11454 | — |
| 반응물 | HCID 178445912 | HCID 178445912 | — |
| 생성물 | (2R)-2-[{2-Amino-5-[(1-phenylethyl)thio][1,3]thiazolo[4,5-d]pyrimidin-7-yl}(methyl)amino]-4-methylpentan-1-ol | HCID 11965770 | 62% |
반응 단계
The title compound was synthesized as a mixture of two diastereomers by general method A from the reaction of (2R)-2-[(2-amino-5-mercapto[1,3]thiazolo[4,5-d]pyrimidin-7-yl)(methyl)amino]-4-methylpentan-1-ol (31.4 mg, 0.1 mmol) with 1-bromoethylbenzene (13.5 μL, 0.1 mmol) to give 26 mg (62% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09440992B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-b40751796cd245b18d9f8f37ad7450a5 |
| 출처 메모 | uspto-grants-2016_09 |