Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formaldehyde → [4-[1-(Tert-butyldimethylsilanyloxy)hexyl]phenyl]methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | ((1-(4-Bromophenyl)hexyl)oxy)(tert-butyl)dimethylsilane | HCID 57438973 | — |
| 반응물 | HCID 178418306 | HCID 178418306 | — |
| 용매 | Pentane | HCID 8003 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | [4-[1-(Tert-butyldimethylsilanyloxy)hexyl]phenyl]methanol | HCID 67046104 | 69% |
반응 단계
tert-Butyllithium (6.6 mL of a 1.7 M solution in pentane, 11.32 mmol) was added to a solution of the aryl bromide 7 (2.0 g, 5.39 mmol) in THF (22 mL) at −78° C. After 0.5 h paraformaldehyde (323 mg, 8.09 mmol) was added. The reaction was warmed to room temperature and stirred for 16 h. The reaction was quenched with saturated aqueous NH4Cl and extracted with EtOAc. The organic portion was dried (MgSO4), filtered and concentrated in vacuo. FCC (silica gel, 6:1 hex/EtOAc) yielded 1.2 g (69%) of the alcohol 8 as a clear, colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07915316B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-67fbe19536ed4065ad1c29c3c4d64a78 |
| 출처 메모 | uspto-grants-2011_03 |