Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Amino-2-methylphenol → 7-Ethoxy-4-[(3-hydroxy-4-methylphenyl)amino]-6-methoxy-3-quinolinecarbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Amino-2-methylphenol | HCID 17818 | — |
| 반응물 | 4-Chloro-7-ethoxy-6-methoxy-3-quinolinecarbonitrile | HCID 10563473 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 7-Ethoxy-4-[(3-hydroxy-4-methylphenyl)amino]-6-methoxy-3-quinolinecarbonitrile | HCID 22466752 | 54.8% |
반응 단계
A mixture of 500 mg (1.90 mmol) 4chloro-7ethoxy-6-methoxy-3-quinolinecarbonitrile, 30 ml ethanol, and 281 mg (2.28 mmol) 3-hydroxy-4-methylaniline was heated to reflux under N2 overnight. Removed heat and made basic with saturated sodium bicarbonate. Stripped solvents and slurried residue in hexane. Collected solids, washed with water, and dried in vacuo, giving 364 mg off-white solid: mass spectrum (electrospray m/e): M+H=349.9.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06002008 |
| 출처 데이터셋 | uspto-grants-1999_12 |
| ORD ID | ord-2257594767904b8c8d0de3e04236adb3 |
| 출처 메모 | uspto-grants-1999_12 |