참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | (R)-Methyl 2-amino-3-phenylpropanoate | HCID 853474 | — |
| 촉매 | L-Phenylalanine, methyl ester | HCID 736234 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | methyl (2R)-2-amino-3-phenylpropanoate;hydrochloride | HCID 11481330 | 78.8% |
반응 단계
An aqueous solution of 153.2 mmol of D-phenylalanine methyl ester and 4.6 mmol of L-phenylalanine methyl ester (D/L ratio=97.1/2.9) and 335 mmol of HCl in 400 ml of pure water was neutralized to pH 3 with a 20% NaOH aqueous solution and concentrated to a weight of 100 g by means of a rotary evaporator. The concentrate was cooled to about 2° C., and the precipitated crystals were collected by filtration by suction. There was obtained 120.7 mmol of D-phenylalanine methyl ester hydrochloride having an optical purity of 99.97% as measured by HPLC.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06008403 |
|---|
| 출처 데이터셋 | uspto-grants-1999_12 |
|---|
| ORD ID | ord-a88b643517434cb992fa6cae6c5fd4a5 |
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| 출처 메모 | uspto-grants-1999_12 |
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