Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Norfloxacin → 1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid pentahydrate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Norfloxacin | HCID 4539 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | 1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid pentahydrate | HCID 70603524 | — |
반응 단계
The compound (II) was dissolved in 10% sodium hydroxide and neutralized with acetic acid. The precipitate was washed with water and dried at room temperature to afford 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrate (I) as colorless powder, m.p.: 226°-227° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04146719 |
| 출처 데이터셋 | uspto-grants-1979_03 |
| ORD ID | ord-cd84b54551eb4287bbcf73cd49f6b746 |
| 출처 메모 | uspto-grants-1979_03 |