Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(2,3-Epoxypropoxy)-4-(2-methoxyethoxy)benzene → 1-[N-[2-(3-carbamoyl-4-hydroxyphenoxy)-1-methylethyl]benzylamino]-3-[4-(2-methoxyethoxy)phenoxy]-propan-2-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(2,3-Epoxypropoxy)-4-(2-methoxyethoxy)benzene | HCID 12621549 | — |
| 반응물 | 5-(2-Benzylaminopropoxy)salicylamide | HCID 13754334 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 1-[N-[2-(3-carbamoyl-4-hydroxyphenoxy)-1-methylethyl]benzylamino]-3-[4-(2-methoxyethoxy)phenoxy]-propan-2-ol | HCID 13754335 | — |
반응 단계
A solution of 10.2 g of 1-(2,3-epoxypropoxy)-4-(2-methoxyethoxy)benzene and 11.0 g of 5-[2-(benzylamino)-propoxy]salicylamide in 200 ml of isopropanol is refluxed for 24 hours. By concentration of the solution by evaporation, crude 1-[N-[2-(3-carbamoyl-4-hydroxyphenoxy)-1-methylethyl]benzylamino]-3-[4-(2-methoxyethoxy)phenoxy]-propan-2-ol is obtained as an oil which is used in its crude state for debenzylation.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04497813 |
| 출처 데이터셋 | uspto-grants-1985_02 |
| ORD ID | ord-943dba6da96f4f08b68ce8ac9d39c937 |
| 출처 메모 | uspto-grants-1985_02 |