Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(2-Chlorophenoxymethyl)oxirane → 1-[3-(o-Chloro-phenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(2-Chlorophenoxymethyl)oxirane | HCID 137500 | — |
| 반응물 | 1-(Piperidin-4-yl)-1,3-diazinan-2-one | HCID 15572666 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1-[3-(o-Chloro-phenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine | HCID 20368054 | — |
반응 단계
A solution of 9.2 g of 1-(o-chloro-phenoxy)-2,3-epoxy-propane and 9.15 g of 1-(4-piperidyl)-2-oxo-hexahydro-pyrimidine in 7 ml of abs. ethanol is heated for 5 hours to 95° C and then evaporated in vacuo. The residue is recrystallised from chloroform/petroleum ether to yield the 1-[3-(o-chloro-phenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine, which melts at 150°-153° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04075335 |
| 출처 데이터셋 | uspto-grants-1978_02 |
| ORD ID | ord-6351b52759b7494a976e3ade071d5620 |
| 출처 메모 | uspto-grants-1978_02 |