Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 61732생성일: 2026년 10월 23일
1-Isopropylpiperazine → 8-(4-isopropylpiperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
https://huagongshe.com/ko/reaction/61732
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Isopropylpiperazine | HCID 78013 | — |
| 반응물 | Trifluoro-methanesulfonic acid 3-cyano-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl ester | HCID 86663817 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 8-(4-isopropylpiperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile | HCID 49805004 | — |
반응 단계
Trifluoro-methanesulfonic acid 3-cyano-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl ester (Compound B1, 40 mg, 0.0921 mmol) was dissolved in NMP (1 ml) and added with 1-isopropylpiperazine (236 mg, 20 eq.). The mixture was stirred at 120° C. for 3 hr. After cooling to room temperature, purification was carried out by HPLC to obtain the target compound (white powder, 12.8 mg, 34%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09440922B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-f6bef84f4e634f30a2ee33747ce7b2c4 |
|---|
| 출처 메모 | uspto-grants-2016_09 |
|---|
