Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Hydroxyquinoline → HCID 21309661, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Hydroxyquinoline | HCID 11376 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | N-(tert-Butoxycarbonyl)-D-prolinol | HCID 688279 | — |
| 반응물 | Diethyl azodicarboxylate | HCID 5462977 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 21309661 | HCID 21309661 | — |
반응 단계
A 2.77 g sample of (R)-1-t-butoxycarbonyl-2-pyrrolidinemethanol and 3 g of 3-hydroxyquinoline were reacted with triphenylphosphine and DEAD in 100 mL of THF according to the procedure of Example 14a, to give 2.5 g of the title compound. MS (DCI/NH3) m/e 329 (M+H)+. 1H NMR (CDCl3, 300 MHz) δ: 8.67 (d, J=3 Hz 1H), 8.4 (d, J=7 Hz, 1H), 7.72 (dd, J=7, 1 Hz 1H), 7.56-7.40 (m, 3H), 4.24-3.94 (m, 3 H), 3.42 (bs 2H), 2.11-1.94 (m 3H), 1.92-1.48 (m 1H), (s 9H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05948793 |
| 출처 데이터셋 | uspto-grants-1999_09 |
| ORD ID | ord-80448b942d2e43a8918365bfd7098250 |
| 출처 메모 | uspto-grants-1999_09 |