참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 3',4',5'-Trimethoxyacetophenone | HCID 14345 | — |
| 반응물 | 5-nitro-1H-indole-3-carbaldehyde | HCID 246039 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (E)-3-(5-Nitroindol-3-yl)-1-(3,4,5-trimethoxyphenyl)-2-propen-1-one | HCID 21850180 | 5.3% |
반응 단계
3',4',5'-Trimethoxyacetophenone (1.31 g) and 5-nitroindole-3-carboxaldehyde (1.18 g) were dissolved in N,N-dimethylformamide (20 ml), and piperidine (528.7 mg) was added thereto, followed by stirring at 100° C. for 72 hours. The reaction solution was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography. The obtained crude crystals were recrystallized from methanol to give Compound 21 (125 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05952355 |
|---|
| 출처 데이터셋 | uspto-grants-1999_09 |
|---|
| ORD ID | ord-e5fc7ad1fae14f72a4885117db483730 |
|---|
| 출처 메모 | uspto-grants-1999_09 |
|---|
