Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 3-(4-Trifluoromethylbenzamido)propan-1-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3-Amino-1-propanol | HCID 9086 | — |
| 반응물 | 4-(Trifluoromethyl)benzoyl chloride | HCID 67607 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-(4-Trifluoromethylbenzamido)propan-1-ol | HCID 22006830 | 85% |
반응 단계
A reaction vessel was charged with 7.51 g of 3-amino-1-propanol, 2.53 g of triethylamine and 50 ml of dichloromethane, and 5.21 g of 4-trifluoromethylbenzoyl chloride was slowly added dropwise under ice cooling. After stirring at room temperature for 6 hours, the reaction mixture was successively washed with diluted hydrochloric acid and water, dried over anhydrous magnesium sulfate, and then concentrated, which afforded 5.25 g of 3-(4-trifluoromethylbenzamido)propan-1-ol (85% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05952386 |
| 출처 데이터셋 | uspto-grants-1999_09 |
| ORD ID | ord-76ee336123e34623bfc57fb3c8e6cf87 |
| 출처 메모 | uspto-grants-1999_09 |