Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester → 5-Amino-1-(3,5-dichloro-pyrid-2-yl)-4-ethoxycarbonyl-pyrazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester | HCID 78943 | — |
| 반응물 | 3,5-Dichloro-2-hydrazinylpyridine | HCID 600966 | — |
| 용매 | 1-Ethoxyethanol | HCID 10129898 | — |
| 생성물 | 5-Amino-1-(3,5-dichloro-pyrid-2-yl)-4-ethoxycarbonyl-pyrazole | HCID 13755230 | 98.3% |
반응 단계
16.9 g (0.1 mole) of ethyl ethoxymethylenecyanoacetate and 17.8 g (0.1 mole) of 3,5-dichloro-pyrid-2-ylhydrazine in 150 ml of ethoxyethanol are stirred at 80° C. for 5 hours and then at 120° C. for a further 2 hours. For working up, the solvent is removed in vacuo. 29.6 g (98% of theory) of 5-amino-1-(3,5-dichloro-pyrid-2-yl)-4-ethoxycarbonyl-pyrazole of melting point 98°-101° C. are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04772312 |
| 출처 데이터셋 | uspto-grants-1988_09 |
| ORD ID | ord-c998c34efefb4ee99bb0ca2dbd3a393b |
| 출처 메모 | uspto-grants-1988_09 |