Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 4-Chloro-N-methoxy-N-methylbenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 4-Chlorobenzoyl chloride | HCID 8501 | — |
| 반응물 | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-Chloro-N-methoxy-N-methylbenzamide | HCID 11275663 | — |
반응 단계
Pyridine (27.6 mL, 343 mmol) was added to N,O-dimethylhydroxylamine hydrochloride (16.7 g, 172 mmol) in DCM (400 mL). 4-Chlorobenzoyl chloride (20 mL, 156 mmol) was then added and the mixture was stirred at room temperature for 3 days. Solids were removed by vacuum filtration, washing with DCM. The filtrate was washed with 1 N aqueous HCl followed by water. The organic phase was dried (Na2SO4), filtered, and concentrated, affording the crude title compound as a colorless liquid which was used without purification in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09303015B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-0b43466913e84e2bae57fdc66e5da223 |
| 출처 메모 | uspto-grants-2016_04 |