Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl Chloride → Methyl 2-(4-benzyloxyphenyl)acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl Chloride | HCID 7503 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Benzeneacetic acid, 4-hydroxy-, methyl ester | HCID 518900 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Methyl 2-(4-benzyloxyphenyl)acetate | HCID 2756645 | 91% |
반응 단계
(4-Hydroxy-phenyl)-acetic acid methyl ester (1.0 g, 6.02 mmol) was dissolved in DMF (10 mL), and K2CO3(2.5 g, 18.06 mmol) was added thereto. Benzyl chloride (0.83 mL, 7.22 mmol) was added slowly thereto, and the mixture was stirred at 40˜50° C. for 12 hours. The reactant was cooled and concentrated under reduced pressure. The residue was added with water and then extracted with EtOAc. The organic layer was concentrated under reduced pressure, and the residue was purified by column chromatography (eluent, EtOAc/Hex=1/4) to obtain the title compound (1.4 g, 91%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09447044B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-71af20cbfa714d0c9ff47fe7831bd641 |
| 출처 메모 | uspto-grants-2016_09 |