참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Cyclohexanethiol | HCID 15290 | — |
| 반응물 | Methyl 6-bromopyridine-2-carboxylate | HCID 16217886 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 6-Cyclohexylsulfanyl-pyridine-2-carboxylic acid methyl ester | HCID 90118251 | 46.4% |
반응 단계
After 6-bromo-pyridine-2-carboxylic acid methyl ester (0.30 g, 1.39 mmol) was dissolved in DMF (4 mL), K2CO3(0.575 g, 4.16 mmol) and cyclohexanethiol (0.25 mL, 2.08 mmol) were added thereto in turn, and the mixture was stirred at 70° C. for 18 hours. After the termination of the reaction, the reactant was concentrated under reduced pressure, extracted with EtOAc, and purified by column chromatography (eluent, EtOAc/Hex=1/5) to obtain the title compound (0.162 g, 46%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09447044B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-5de57498ae4f48acbce22a701ea55cc6 |
|---|
| 출처 메모 | uspto-grants-2016_09 |
|---|
