Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate → 3-[4-(2-t-Butylsulfanyl-pyridin-3-ylmethoxy)-3,5-difluoro-phenyl]-propionic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate | HCID 23136305 | — |
| 반응물 | 2-t-Butylsulfanyl-3-chloromethyl-pyridine | HCID 90118202 | — |
| 생성물 | 3-[4-(2-t-Butylsulfanyl-pyridin-3-ylmethoxy)-3,5-difluoro-phenyl]-propionic acid ethyl ester | HCID 90118671 | 86% |
반응 단계
2-t-Butylsulfanyl-3-chloromethyl-pyridine (0.08 g, 0.37 mmol) obtained in Step C of Preparation Example 17 and 3-(3,5-difluoro-4-hydroxy-phenyl)-propionic acid ethyl ester obtained in Step D of Preparation Example 2 were used to react in the same manner as in Step A of Example 1 to obtain the title compound (0.13 g, 86%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09447044B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-867258840b3d4f1691395980e6e92a31 |
| 출처 메모 | uspto-grants-2016_09 |