Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 4-Bromo-2-(bromomethyl)-1-chlorobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Benzoyl Peroxide | HCID 7187 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 5-Bromo-2-chlorotoluene | HCID 609899 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 생성물 | 4-Bromo-2-(bromomethyl)-1-chlorobenzene | HCID 11558280 | 70% |
반응 단계
A mixture of 4-bromo-1-chloro-2-methylbenzene (5.0 g, 24.0 mmol), N-bromosuccinimide (4.4 g, 25.0 mmol), and benzoyl peroxide (700 mg, 2.9 mmol) in anhydrous carbon tetrachloride (85 mL) was stirred at reflux for 4 hours. Dichloromethane (50 mL) was added. The mixture was extracted with 1 N NaOH (1×150 mL) and brine (1×150 mL). The organic extract was recovered, dried over MgSO4, filtered, evaporated, and dried in vacuo. The crude product was purified by flash chromatography (0-5% EtOAc/hexanes), affording 4-bromo-2-(bromomethyl)-1-chlorobenzene (4.76 g, 70% yield). The product was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09315521B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-ed3849c3768241ef9ae0d89b7e3ab53d |
| 출처 메모 | uspto-grants-2016_04 |