Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Fluoroaniline → 2-chloro-5-ethyl-N-(4-fluorophenyl)-6-methylpyrimidin-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Fluoroaniline | HCID 9731 | — |
| 반응물 | 2,4-Dichloro-5,6-dimethylpyrimidine | HCID 241553 | — |
| 반응물 | 2-chloro-N-cyclohexyl-5,6-dimethylpyrimidin-4-amine | HCID 82460626 | — |
| 반응물 | 2,4-Dichloro-5-ethyl-6-methylpyrimidine | HCID 89761070 | — |
| 생성물 | 2-chloro-5-ethyl-N-(4-fluorophenyl)-6-methylpyrimidin-4-amine | HCID 117817658 | — |
반응 단계
The titled compound was synthesized according to the procedure described for preparation of 2-chloro-N-cyclohexyl-5,6-dimethylpyrimidin-4-amine (Example 1, Step D) using 2,4-dichloro-5-ethyl-6-methylpyrimidine instead 2,4-dichloro-5,6-dimethylpyrimidine and 4-fluoroaniline instead of cyclohexylamine. The titled compound was obtained as a white solid. MS (ESI) m/z 266.7, 268.7 (M+1)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09447051B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-7d6665336df9400aabbf57fe305a1b62 |
| 출처 메모 | uspto-grants-2016_09 |