Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
L-phenylalanine cyclopentyl ester tosylate → cyclopentyl N-[2-(1-{[2,4-dihydroxy-5-(propan-2-yl)phenyl]carbonyl}piperidin-4-yl)ethyl]-L-phenylalaninate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | L-phenylalanine cyclopentyl ester tosylate | HCID 86629432 | — |
| 반응물 | 2-(1-{[2,4-Bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidin-4-yl)acetaldehyde | HCID 86686420 | — |
| 생성물 | cyclopentyl N-[2-(1-{[2,4-dihydroxy-5-(propan-2-yl)phenyl]carbonyl}piperidin-4-yl)ethyl]-L-phenylalaninate | HCID 54766972 | — |
반응 단계
Prepared from Intermediate D and L-phenylalanine cyclopentyl ester tosylate. 1H NMR (300 MHz, d3-MeOD) 7.44-7.17 (5H, m), 6.95 (1H, s), 6.34 (1H, s), 5.17, (1H, m), 4.35-4.12 (4H, m), 3.46-3.35 (1H, m), 3.27-2.85 (6H, m), 1.93-1.21, (13H, m), 1.19 (6H, d, J=7.0 Hz). LC/MS: purity 98.4%, m/z 523 [M+H]+
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09321718B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-180aeae9063a4499a5dcb418e860a8db |
| 출처 메모 | uspto-grants-2016_04 |