Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
L-Alanine 1,1-dimethylethyl ester → tert-butyl N-[2-(1-{[2,4-dihydroxy-5-(propan-2-yl)phenyl]carbonyl}piperidin-4-yl)ethyl]-L-alaninate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | L-Alanine 1,1-dimethylethyl ester | HCID 89016 | — |
| 반응물 | 2-(1-{[2,4-Bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidin-4-yl)acetaldehyde | HCID 86686420 | — |
| 생성물 | tert-butyl N-[2-(1-{[2,4-dihydroxy-5-(propan-2-yl)phenyl]carbonyl}piperidin-4-yl)ethyl]-L-alaninate | HCID 54766975 | — |
반응 단계
Prepared from Intermediate D and L-alanine tert-butyl ester. 1H NMR (300 MHz, d3-MeOD) 6.96 (1H, s), 6.33 (1H, s), 4.17 (2H, m), 3.19 (3H, m), 2.95 (2H, t, J=12.0 Hz), 2.60 (2H, m), 1.78 (4H, m), 1.50 (9H, m), 1.27 (3H, d, J=6.9 Hz), 1.23 (2H, m), 1.18 (6H, d, J=6.9 Hz). LC/MS: purity 98%, m/z 435 [M+H]+
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09321718B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-c55b55f0951e4f78904c18b8a4151ac8 |
| 출처 메모 | uspto-grants-2016_04 |