Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloromethyl Methyl Ether → 1,2-Dimethoxy-4-(methoxymethoxy)benzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloromethyl Methyl Ether | HCID 7864 | — |
| 반응물 | 3,4-Dimethoxyphenol | HCID 16251 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1,2-Dimethoxy-4-(methoxymethoxy)benzene | HCID 14910566 | — |
반응 단계
To a stirred solution of 3,4-bis(methyloxy)phenol (Commercial eg Alfa Aesar) (1.0 g) and DIPEA (2.28 ml) in DCM (15 ml) was added chloromethyl methyl ether (0.74 ml) at 0 C. After stirring at 25-30 C. for 17 h, the reaction was washed with dilute hydrochloric acid and saturated aqueous sodium bicarbonate. This was dried over sodium sulphate and purified through silica eluting with 0-5% ethyl acetate in hexane, to give the title compound, 0.80 g
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09447074B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-4b50b033a95a448ea8fd081aada03c0c |
| 출처 메모 | uspto-grants-2016_09 |