Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(Bromomethyl)-4-(1,1-dimethylethyl)benzene → 1-(4-(tert-butyl)benzyl)-5-(1H-pyrazol-4-yl)indoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(Bromomethyl)-4-(1,1-dimethylethyl)benzene | HCID 87836 | — |
| 반응물 | 5-Bromoindoline | HCID 3411566 | — |
| 반응물 | tert-butyl 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate | HCID 16217654 | — |
| 반응물 | 1-(4-Isopropylbenzyl)-5-(1H-pyrazol-4-yl)indoline | HCID 90011062 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 생성물 | 1-(4-(tert-butyl)benzyl)-5-(1H-pyrazol-4-yl)indoline | HCID 90068395 | — |
반응 단계
1-(4-Isopropylbenzyl)-5-(1H-pyrazol-4-yl)indoline, 50 can be prepared by alkylation of 5-bromoindoline, 22 with 1-(bromomethyl)-4-(tert-butyl)benzene using the conditions described in Example 7, part 1 followed by palladium catalyzed coupling of the alkylation product with tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate, 10 followed by hydrolysis using the reaction conditions described in Example 8.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09447069B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-34a0cdaace674f89aedd0d1f89de34d7 |
| 출처 메모 | uspto-grants-2016_09 |