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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 63386생성일: 2026년 10월 24일

Sodium Carbonate → 2-(2-Furanyl)-4,6-dimethylphenol

https://huagongshe.com/ko/reaction/63386

반응식

참여 물질

역할이름HCID투입량
반응물Sodium CarbonateHCID 10340—
반응물2-Bromo-4,6-dimethylphenolHCID 299976—
반응물Furan-2-boronic acidHCID 2734357—
용매Water 1,2-dimethoxyethaneHCID 18180031—
생성물2-(2-Furanyl)-4,6-dimethylphenolHCID 9000279549.3%

반응 조건

온도120 °C

반응 단계

2-Bromo-4,6-dimethylphenol (500 mg, 2.49 mmol), furan-2-ylboronic acid (88 mg, 2.99 mmol), sodium carbonate (791 mg, 7.47 mmol) and Pd2(dppf)2Cl2 (406 mg, 0.49 mmol) were dissolved in dimethoxyethane/water 6 mL/3 mL, followed by stirring in microwave at 120° C. for 20 minutes. After the completion of the reaction, the reaction mixture was filtered using Celite. The filtrate was added with water, and extracted with ethyl acetate. The obtained organic layer was dried over magnesium sulfate, and purified by column chromatography (ethyl acetate:hexane=1:3) to obtain 2-(furan-2-yl)-4,6-dimethylphenol (231 mg, 45%).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09447083B2
출처 데이터셋uspto-grants-2016_09
ORD IDord-806c9ce8c3314d68a408c8e779e4dc1f
출처 메모uspto-grants-2016_09