Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → methyl 4-[(E)-2-(4-pyridyl)vinyl]benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 4-Pyridinecarboxaldehyde | HCID 13389 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | [4-(Methoxycarbonyl)benzyl](triphenyl)phosphonium bromide | HCID 2764257 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | methyl 4-[(E)-2-(4-pyridyl)vinyl]benzoate | HCID 12006312 | — |
| 생성물 | methyl 4-[(Z)-2-(4-pyridyl)vinyl]benzoate | HCID 70244616 | — |
반응 단계
To a solution of sodium hydroxide (830 mg) in dimethylsulfoxide (100 ml) was added (4-methoxycarbonylbenzyl)triphenylphosphonium bromide (10.0 g), and after 30 minutes, 4-pyridinecarbaldehyde (2.22 g) was added thereto under ice-cooling. The mixture was stirred overnight. Water was added to the reaction mixture, and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over magnesium sulfate and concentrated in vacuo. The residue was purified by flash chromatography (n-hexane—ethyl acetate) to give methyl 4-[(E)-2-(4-pyridyl)vinyl]benzoate (1.18 g) and methyl 4-[(Z)-2-(4-pyridyl)vinyl]benzoate (2.67 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06194396B1 |
| 출처 데이터셋 | uspto-grants-2001_02 |
| ORD ID | ord-61dcf52438ce4715b2d32a7ba6886700 |
| 출처 메모 | uspto-grants-2001_02 |