Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Hydroxide → 6-(2-Methoxy-ethoxy)-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | Methyl 6-bromo-5-chloro-2-pyrazinecarboxylate | HCID 59254839 | — |
| 반응물 | 6-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid | HCID 68567445 | — |
| 용매 | 2-Methoxyethanol | HCID 8019 | — |
| 생성물 | 6-(2-Methoxy-ethoxy)-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid | HCID 68565209 | 17% |
반응 단계
In analogy to the procedure described for the synthesis of 6-propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid (example 10, step c), the title compound was synthesized from 6-bromo-5-chloro-pyrazine-2-carboxylic acid methyl ester, 2-methoxy-ethanol (commercially available), pyrrolidine (commercially available) and subsequent saponification with KOH in 17% yield. m/z (ES+): 268.0 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07691863B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-852fc84383f341a4a317ffb1ec1f8e6d |
| 출처 메모 | uspto-grants-2010_04 |