Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosphorus oxychloride → 4-Chloro-2-methylquinazolin-8-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 8-Hydroxy-2-methyl-4(3H)-quinazolinone | HCID 135398517 | — |
| 생성물 | 4-Chloro-2-methylquinazolin-8-ol | HCID 53426527 | — |
반응 단계
8-Hydroxy-2-methyl-4(3H)-quinazolinone (0.01 mol) and phosphorus oxychloride (10 mL) were heated under reflux for 30 min. The excess phosphorus oxychloride was removed under reduce pressure and the residue was added to a mixture of ice (50 g) and water (50 ml), and the pH adjusted to 6 (aqueous ammonia). 4-Chloro-8-hydroxy-2-methyl-quinazoline (A2) was isolated via filtration.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07692011B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-5161bd596ee2450195d9187883481e1d |
| 출처 메모 | uspto-grants-2010_04 |