참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | L-Lactic Acid | HCID 107689 | — |
| 반응물 | (2R)-2-Hydroxy-2-methyl-3-phenylpropanoic acid | HCID 11286816 | — |
| 반응물 | HCID 178418581 | HCID 178418581 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Benzyl lactate | HCID 98054 | 95% |
반응 단계
Construction of Benzyl-L-lactic Acid. L-Lactic acid (9 g, 100 mmol) is added to N,N'-diisopropylbenzylisourea (23.3 g, 100 mmol) with stirring. The mixture becomes very viscous within 10 min and is stirred intermittently for 1 h. The volume is then increased to 200 mL with THF, and the mixture stirred for 48 h at room temperature. After cooling the mixture to -15° C., the diisopropylurea is removed by filtration and the THF is evaporated under reduced pressure. The resulting thick oil is pumped under high vacuum for 24 h to give benzyl lactate (17.4 g, 95%) which may be used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05248761 |
|---|
| 출처 데이터셋 | uspto-grants-1993_09 |
|---|
| ORD ID | ord-9f8135fc2ea3458ea13011035828fec5 |
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| 출처 메모 | uspto-grants-1993_09 |
|---|
