Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 64284생성일: 2026년 10월 24일
Potassium Carbonate → 7-(2-Aminophenyl)-2-(4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carbonitrile
https://huagongshe.com/ko/reaction/64284
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Bromomethylcyclopropane | HCID 81503 | — |
| 반응물 | 7-(2-Aminophenyl)-2-(4-hydroxyphenyl)-4,5,6,7-tetrahydro pyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 136928089 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 7-(2-Aminophenyl)-2-(4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 136928073 | 78% |
반응 단계
To a solution of 7-(2-aminophenyl)-2-(4-hydroxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carbonitrile (331 mg, 1.0 mmol) in acetone (15 mL) was added (bromomethyl)cyclopropane (135 mg, 1.0 mmol) and K2CO3 (276 mg, 2.0 mmol). After stirring at 56° C. for 16 hr, the mixture was filtered. The cake was washed with acetone (20 mL×2). The filtrate was concentrated to afford 300 mg of desired product (78%) as a yellow solid. MS (ESI) m/e [M+1]+ 386.0.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09447106B2 |
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| 출처 데이터셋 | uspto-grants-2016_09 |
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| ORD ID | ord-6d2837b89b9b4bf5a7fd11f429669c20 |
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| 출처 메모 | uspto-grants-2016_09 |
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