Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl 2-formyl-3-oxopropanoate → Ethyl 3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl 2-formyl-3-oxopropanoate | HCID 11029955 | — |
| 반응물 | HCID 178509389 | HCID 178509389 | — |
| 촉매 | Acetic Acid | HCID 176 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Ethyl 3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxylate | HCID 117668240 | 65% |
반응 단계
To a solution of 5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (276 mg, 1.0 mmol) in EtOH (10 mL) was added ethyl 2-formyl-3-oxopropanoate (144 mg, 1.0 mmol) and HOAc (5 drops). After stirring at RT for 16 hr, the mixture was filtered. The cake was washed with H2O (10 mL×2) and dried to afford 250 mg (65%) of ethyl 3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxylate as a yellow solid. MS (ESI) m/e [M+1]+ 384.9.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09447106B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-0baf4cc1548944759b9bcc143c0563eb |
| 출처 메모 | uspto-grants-2016_09 |