Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonium Chloride → tert-Butyl 4-hydroxy-3,3-dimethylpiperidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | tert-Butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate | HCID 22278899 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | tert-Butyl 4-hydroxy-3,3-dimethylpiperidine-1-carboxylate | HCID 53393265 | 96% |
반응 단계
To a stirring solution of 1-Boc-3,3-dimethylpiperidin-4-one (0.48 g, 2.1 mmol) in methanol (20 mL) at 0° C., was added sodium borohydride (0.096 g, 2.5 mmol). After 1 h, satd aq ammonium chloride (1 mL) was added and the solution was concentrated in vacuo. The residue was flushed through a pad of silica gel, eluting with ethyl acetate and the filtrate was concentrated in vacuo to give 0.46 g (96%) of a clear colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07700628B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-ba77462b0e6e43a2ab986ef289811f3d |
| 출처 메모 | uspto-grants-2010_04 |