Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric acid magnesium salt (1:1) → methyl 3-[(E)-[(S)-tert-butylsulfinyl]iminomethyl]benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 반응물 | Methyl 3-formylbenzoate | HCID 639145 | — |
| 반응물 | tert-Butylsulfinamide, (S)-(-)- | HCID 11355477 | — |
| 촉매 | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | methyl 3-[(E)-[(S)-tert-butylsulfinyl]iminomethyl]benzoate | HCID 90072367 | 61.4% |
반응 단계
A suspension of 3.0 g of methyl 3-formylbenzoate, 2.5 g of (S)-2-methyl-2-propanesulfinamide, 250 mg of pyridinium paratoluene sulfonate, and 11 g of magnesium sulfate in 50 ml of dichloromethane was stirred overnight. The reaction mixture was filtered over Celite and the solvent was then evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain 3.0 g of methyl 3-[(E)-{[(S)-tert-butylsulfinyl]imino}methyl]benzoate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09447090B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-ae2adc3ef3c44339aeffce4f7d770d98 |
| 출처 메모 | uspto-grants-2016_09 |