Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Iodide → 2-iodo-9-(pyridin-2-yl)-9H-carbazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | 1-N,2-N-dimethylcyclohexane-1,2-diamine | HCID 551074 | — |
| 반응물 | 2-bromo-9-(pyridin-2-yl)-9H-carbazole | HCID 70654852 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-iodo-9-(pyridin-2-yl)-9H-carbazole | HCID 121409855 | 83.1% |
반응 단계
A 100 ml three neck round bottom flask was charged with 2-bromo-9-(pyridin-2-yl)-9H-carbazole (10.15 g, 31.4 mmol), copper(I) iodide (1.196 g, 6.28 mmol), N1,N2-dimethylcyclohexane-1,2-diamine (1.981 ml, 12.56 mmol), sodium iodide (18.83 g, 126 mmol), and Dioxane (60 ml.). The reaction mixture was then heated to reflux for 18 hours. The reaction mixture was diluted with deionized water and extracted with ethyl acetate. The organic portion was combined and subjected to column chromatography (SiO2, 50%/DCM in heptane) to yield 2-iodo-9-(pyridin-2-yl)-9H-carbazole (9.66 g, 83%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09450195B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-64a4c0300e1c4dfc9a5fefb5a8c9395c |
| 출처 메모 | uspto-grants-2016_09 |