Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Reserpine → 2-(2-Fluoropyridin-3-yloxy)nicotinonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Reserpine | HCID 5770 | — |
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | 2-Fluoro-3-hydroxypyridine | HCID 2762785 | — |
| 생성물 | 2-(2-Fluoropyridin-3-yloxy)nicotinonitrile | HCID 68679245 | — |
반응 단계
The title compound was synthesized by General Procedure 9 using 2-fluoro-3-hydroxypyridine. 1H NMR (DMSO-d6. 400 MHz) δ 7.41 (dd, 1H, J=5.0 Hz, J=7.6 Hz), 7.51 (ddd, 1H, J=1.1 Hz, J=4.9 Hz, J=7.8 Hz), 8.09 (ddd, 1H, J=1.7 Hz, J=7.8 Hz, J=9.7 Hz), 8.19 (td, 1H, J=1.6 Hz, J=4.9 Hz), 8.42 (dd, 1H, J=1.9 Hz, J=5.0 Hz), 8.50 (dd, 1H, J=1.9 Hz, J=7.6 Hz); RP-HPLC (Hypersil®1-100 C18, 5 μm, 100 Å, 10 cm; 5%-100% acetonitrile-0.1M ammonium acetate over 5 min. 2 mL/min), then 100% acetonitrile isocratic 1 minutes, Rt 3.62 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07704997B1 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-03fa5e3ee3b7490c93c65bd7c6d03996 |
| 출처 메모 | uspto-grants-2010_04 |