Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 645683생성일: 2026년 10월 24일
Chlorotrimethylsilane → 1-(4-(4-(1H-indazol-6-ylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)piperidin-4-ol
https://huagongshe.com/ko/reaction/645683
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Chlorotrimethylsilane | HCID 6397 | — |
| 반응물 | 1-(4-Aminophenyl)piperidin-4-ol | HCID 16792107 | — |
| 반응물 | 2-chloro-N-(1H-indazol-6-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | HCID 86628035 | — |
| 용매 | 1-Butanol | HCID 263 | — |
| 생성물 | 1-(4-(4-(1H-indazol-6-ylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)piperidin-4-ol | HCID 68581516 | 13.2% |
반응 단계
A mixture of 2-chloro-N-(1H-indazol-6-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (61 mg, 0.14 mmol), 1-(4-aminophenyl)piperidin-4-ol (61 mg, 0.32 mmol) and trimethylsilyl chloride (TMSCl) (0.060 mL, 0.48 mmol) in n-butyl alcohol (2 mL) was heated at 116° C. for 96 h. The mixture was then purified by HPLC to give 1-(4-(4-(1H-indazol-6-ylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)piperidin-4-ol (11 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07705004B2 |
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| 출처 데이터셋 | uspto-grants-2010_04 |
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| ORD ID | ord-a3781f68157f452cab4c358a3ae95c3f |
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| 출처 메모 | uspto-grants-2010_04 |
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