Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(1-Pyrrolidinyl)piperidine → cis-[2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(1-Pyrrolidinyl)piperidine | HCID 78703 | — |
| 반응물 | 2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride | HCID 86613632 | — |
| 생성물 | cis-[2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone | HCID 24775343 | — |
반응 단계
cis-4-[2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 20) was reacted with 4-pyrrolidin-1-yl-piperidine (Aldrich) to give cis-[2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone in an analogous manner as described in example 1. HR-MS (ES, m/z) calculated for C35H42N6O2Cl2 [(M+H)+] 649.2819, observed 649.2822.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07705007B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-d111b35deed0498e936c7116fc98fc95 |
| 출처 메모 | uspto-grants-2010_04 |