Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 1,2,3,4-Tetrahydro-1-methylquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | 1,2,3,4-Tetrahydroquinoline | HCID 69460 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 1,2,3,4-Tetrahydro-1-methylquinoline | HCID 68109 | — |
반응 단계
1,2,3,4-tetrahydroquinoline (2.0 g, 0.0015 mol) and formaldehyde (12 ml of 38% aqueous, 0.015 mol) were combined in 60 ml CH3CN. NaBH3CN (2.85 g) and then, over a 10 minute period, glacial acetic acid (1.50 ml) were added and the mixture stirred 2 hours, at which time additional acetic acid (0.5 ml) was added. After stirring an additional 30 minutes, the reaction mixture was poured into 200 ml ether, washed 3×30 ml IN NaOH, dried (K2CO3) and stripped in vacuo to yield title product, 2.27 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04738972 |
| 출처 데이터셋 | uspto-grants-1988_04 |
| ORD ID | ord-85419eeb82a746f786df9b99a5e207be |
| 출처 메모 | uspto-grants-1988_04 |