Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chlorobenzylamine → 1-Chloro-2-(isocyanatomethyl)benzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chlorobenzylamine | HCID 66648 | — |
| 반응물 | Triphosgene | HCID 94429 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-Chloro-2-(isocyanatomethyl)benzene | HCID 2733367 | 232.7% |
반응 단계
To a solution of 2-chlorobenzylamine (1.0 g, 7.06 mmol) in a mixture of CH2Cl2 and H2O (10 mL/10 mL), triphosgene (838 mg, 2.82 mmol) and NaHCO3 (1.78 g, 21.2 mmol) were added. The reaction mixture was stirred at room temperature for 16 hours. Then the reaction mixture was partitioned between CH2Cl2 and water. The combined organic layers are dried over MgSO4 and filtered. The solvent was evaporated to give the desired product (1.1 g, 93%). EI-MS m/z 168.7 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06271261B1 |
| 출처 데이터셋 | uspto-grants-2001_08 |
| ORD ID | ord-291c8d96be1d44cfb70e9e6690479ef3 |
| 출처 메모 | uspto-grants-2001_08 |