Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → 4-n-Butylidene-4,5,6,7-tetrahydrobenzo[b]furan
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 4,5,6,7-Tetrahydro-1-benzofuran-4-one | HCID 2733541 | — |
| 반응물 | HCID 178418682 | HCID 178418682 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 4-n-Butylidene-4,5,6,7-tetrahydrobenzo[b]furan | HCID 54518756 | — |
반응 단계
To a mixture of 4-oxo-4,5,6,7-tetrahydrobenzo[b]furan (20.06 g) and THF (200 ml) was added dropwise 2M n-butylmagnesium bromide with ice-water cooling over 15 minutes. The mixture was stirred at r.t. overnight. The reaction mixture was poured into a mixture of a saturated aqueous solution of NH4Cl and AcOEt. The separated organic layer was washed with water and brine, and dried over MgSO4, and evaporated. The resulting oil was purified by chromatography on SiO2 (CHCl3 as eluent) to give 4-n-butylidene-4,5,6,7-tetrahydrobenzo[b]furan as a yellow oil (12.06 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06274619B1 |
| 출처 데이터셋 | uspto-grants-2001_08 |
| ORD ID | ord-274df34808e2475186d75710ee35a1fe |
| 출처 메모 | uspto-grants-2001_08 |