Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ganciclovir → Ganciclovir Di-O-acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ganciclovir | HCID 135398740 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Acetic Anhydride | HCID 7918 | — |
| 생성물 | Ganciclovir Di-O-acetate | HCID 135459822 | 181.5% |
반응 단계
A mixture of 3.00 g of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, 300 mg of 4-dimethylaminopyridine, and 100 ml of acetic anhydride was vigorously stirred for 3 days at room temperature. The acetic anhydride was removed by evaporation at reduced pressure and the residue recrystallized from methanol to give 3.62 g of 9-(1,3-diacetyloxy-2-propoxymethyl)guanine, m.p. 237°-239°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04612314 |
| 출처 데이터셋 | uspto-grants-1986_09 |
| ORD ID | ord-e3e02b987186440aa5444c4ef3accb88 |
| 출처 메모 | uspto-grants-1986_09 |