Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Methoxide → N-[4-(1-Hydroxy-2-(1H-imidazol-1-yl)ethyl]phenyl]methanesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 반응물 | HCID 178505018 | HCID 178505018 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | N-[4-(1-Hydroxy-2-(1H-imidazol-1-yl)ethyl]phenyl]methanesulfonamide | HCID 13763390 | — |
반응 단계
Heat a mixture of 30.83 g (0.097 mole) of (±)-1-[2- hydroxy-2-[4-((methylsulfonyl)amino)phenyl]ethyl-1H-imidazole hydrochloride and 5.24 g (0.097 mole) of sodium methylate in 100 mL of methanol and filter hot through 300 g of alumina (Fisher, neutral, activity III). Wash the alumina with 20% methanol in methylene chloride (200 mL). Concentrate the filtrate in vacuo to afford the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04613609 |
| 출처 데이터셋 | uspto-grants-1986_09 |
| ORD ID | ord-29b50e3c4fe5489bb62b515e2a560803 |
| 출처 메모 | uspto-grants-1986_09 |