참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 6-Bromo-1-(3-methoxypropyl)-1H-indole | HCID 23151674 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3,6-Dibromo-1-(3-methoxypropyl)-1H-indole | HCID 68652832 | — |
반응 단계
A solution of 10.39 g of 6-bromo-1-(3-methoxypropyl)-1H-indole (building block 5) in 1.5 l of tetrahydrofuran is cooled to −78° C., and 7.05 g of N-bromosuccinimide are added. The mixture is stirred at −78° C. for 1.7 hours and then warmed to room temperature. The reaction mixture is evaporated. The title compound is obtained as an orange oil from the residue by flash chromatography (SiO2 60 F). Rf=0.31 (EtOAc-heptane 1:4); Rt=5.65 (Gradient I).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08071651B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_12 |
|---|
| ORD ID | ord-c69ef97162fb406ab0133ecdbc96b27e |
|---|
| 출처 메모 | uspto-grants-2011_12 |
|---|
