Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-((Dimethylamino)methyl)-2-furanmethanol → 2-[[5-(Dimethylamino)methyl-2-furanyl]methoxy]ethanamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-((Dimethylamino)methyl)-2-furanmethanol | HCID 84906 | — |
| 반응물 | 2-Chloroethylamine hydrochloride | HCID 9793737 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-[[5-(Dimethylamino)methyl-2-furanyl]methoxy]ethanamine | HCID 20213312 | — |
반응 단계
A solution of 2-chloroethylamine hydrochloride (6.25 g) in dry dimethylformamide was added dropwise to a stirred, cooled solution of potassium tert-butoxide (8.96 g) and 5-(dimethylamino)methyl-2-furanmethanol (12.4 g) in the same solvent. After 2 hr solvent was removed, the residue basified and extracted with ethyl acetate. The residue after removal of solvent was treated in ethanol with ethanolic oxalic acid. The crystalline salt was recrystallised from ethanol to give 2-[[5-(dimethylamino)methyl-2-furanyl]methoxy]ethanamine, bis oxalate, m.p. 130°-133° (3.05 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04128658 |
| 출처 데이터셋 | uspto-grants-1978_12 |
| ORD ID | ord-31301e6e1b0b47f1a66e9b48bc759747 |
| 출처 메모 | uspto-grants-1978_12 |