Triethylamine → 7-(Trifluoromethyl)quinoline

HRID 657768

반응식

HRID 657768 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.C(N(CC)CC)C>[Pd].CO>[F:15][C:12]([F:13])([F:14])[C:8]1[CH:7]=[C:6]2[C:11]([CH:2]=[CH:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1

참가 물질

5

반응물 2

HCID 8471TriethylamineHCID 676684-Chloro-7-(trifluoromethyl)quinoline

생성물 1

HCID 4596147-(Trifluoromethyl)quinoline

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

4-Chloro-7-(trifluoromethyl)quinoline (9.35 g, 0.0404 mol) was hydrogenated in the presence of 5% palladium on carbon (4 g) in methanol (180 mL) in the presence of triethylamine (6 mL). The solution was stirred for 3.5 hours, and then filtered through Celite. The filtrate was concentrated under reduced pressure, and the residue was treated with ethyl acetate and water. The organic layer was separated, washed with water (2×75 mL), dried over MgSO4, filtered, and concentrated under reduced pressure to a yellow solid.

후처리

  1. filtrationfiltered through Celite
  2. concentrationThe filtrate was concentrated under reduced pressure
  3. additionthe residue was treated with ethyl acetate and water
  4. customThe organic layer was separated
  5. washwashed with water (2×75 mL)
  6. dry with materialdried over MgSO4
  7. filtrationfiltered
  8. concentrationconcentrated under reduced pressure to a yellow solid

출처 및 근거

ORD 기록
ord-7e1175e3eff24a31a75d8f8b247a79c0
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08076345B2

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