참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Methylamine | HCID 6329 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Propane-1-sulphonamide | HCID 3401849 | — |
| 반응물 | N-n-propanesulphonyliminodithiocarbonic acid dimethyl ester | HCID 86736200 | — |
| 반응물 | HCID 178433288 | HCID 178433288 | — |
| 반응물 | HCID 178461087 | HCID 178461087 | — |
| 용매 | Carbon Disulfide | HCID 6348 | — |
| 용매 | Ethanol hexane | HCID 21879635 | — |
| 생성물 | HCID 178461084 | HCID 178461084 | — |
반응 단계
Reaction of n-propanesulphonamide with sodium hydroxide, carbon disulphide and methyliodide by the method described in Example 8 afforded N-n-propanesulphonyliminodithiocarbonic acid dimethyl ester, m.p. 73°-74° (from ethanol-hexane). (Found: C, 31.7; H, 5.7; N, 6.2; S, 42.0. C6H13NO2S3 requires: C, 31.7; H, 5.8; N, 6.2; S, 42.3) (b) The reaction of N-n-propanesulphonyliminodithiocarbonic acid (4.7 g.) dimethyl ester with 4-methyl-5-((2-aminoethyl)thiomethyl)imidazole (3.5 g.) and methylamine by the method described in Example 7 followed by chromatographic purification on a column of silica gel with ethyl acetate-ethanol (4:1) as eluant afforded N-methyl-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-N"-n-propanesulphonylguanidine as a glass (5.0 g.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04129657 |
|---|
| 출처 데이터셋 | uspto-grants-1978_12 |
|---|
| ORD ID | ord-240baad454d847448efc3647cf438761 |
|---|
| 출처 메모 | uspto-grants-1978_12 |
|---|
