Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → Methyl 2-(3-amino-4-hydroxyphenyl)acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Methyl 2-(4-hydroxy-3-nitrophenyl)acetate | HCID 1473109 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Methyl 2-(3-amino-4-hydroxyphenyl)acetate | HCID 1475136 | — |
반응 단계
Methyl-2-(4-hydroxy-3-nitrophenyl)acetate (2.31 g, 10.9 mmol) was dissolved in THF (20 mL) and MeOH (20 mL) and 10% palladium on carbon (210 mg) was added slowly at RT. The reaction mixture was hydrogenated for 2 h at 39 psi hydrogen pressure, filtered through Celite and washed with MeOH. The solvent was removed under a vacuum and the residue purified by means of column chromatography (n-hexane/EA=2:1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08084484B2 |
| 출처 데이터셋 | uspto-grants-2011_12 |
| ORD ID | ord-bac8935b6b8e4d89b1b163b2790afde2 |
| 출처 메모 | uspto-grants-2011_12 |