Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-Allyl-7-hydroxy-8-methoxycoumarin → 7-Acetoxy-6-allyl-8-methoxycoumarin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-Allyl-7-hydroxy-8-methoxycoumarin | HCID 21814500 | — |
| 반응물 | Acetic anhydride pyridine | HCID 22348678 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 7-Acetoxy-6-allyl-8-methoxycoumarin | HCID 21814501 | — |
반응 단계
A solution of 2.32g. (0.010 mole) of 6-allyl-7-hydroxy-8-methoxycoumarin in 8 ml. of chloroform was treated with 4.5 ml. of acetic anhydride/pyridine, 1:2. The reactants were stirred at 25° for 2.0 hours and then partitioned between 1N HCl/methylene chloride. The aqueous phase was further extracted with methylene chloride. The organic extracts were combined, dried over sodium sulfate, and evaporated to afford pure 7-acetoxy-6-allyl-8-methoxycoumarin as a white solid, mp 101°-102°. Recrystallization from ethanol afforded an analytical sample, mp 102°-103°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04130568 |
| 출처 데이터셋 | uspto-grants-1978_12 |
| ORD ID | ord-35cc6a46e79b46c6b636d3fe1c0ddc5b |
| 출처 메모 | uspto-grants-1978_12 |