참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Diethylcarbamoyl chloride | HCID 6916 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-hydroxyisoindolin-1-one | HCID 19900408 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-diethylaminocarbonyloxy-isoindolin-1-one | HCID 22754741 | 57.5% |
반응 단계
The procedure of Example 21 is followed but starting with 2-(7-chloro-1,8-naphthyridin-2-yl)-3-hydroxy-isoindolin-1-one (6.2 g.) in methylene chloride (300 cc.), diethylcarbamoyl chloride (8.15 g.), triethylamine (8.4 cc.) and pyridine (30 cc.). Water (250 cc.) is added to the reaction mixture after it has been stirred for 48 hours at a temperature of about 20° C. The precipitate formed is filtered off and recrystallised from diisopropyl ether (800 cc.) to give 2-(7-chloro-1,8-naphthyridin-2-yl)-3-diethylaminocarbonyloxy-isoindolin-1-one (4.7 g.) melting at 142°-144° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04131674 |
|---|
| 출처 데이터셋 | uspto-grants-1978_12 |
|---|
| ORD ID | ord-5c9a789c3a32422c83bb9b1833d78db1 |
|---|
| 출처 메모 | uspto-grants-1978_12 |
|---|
