Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Bromo-2-methylpropanoic acid → Propanoic acid, 2-((3-(4-chlorophenyl)-1,2-dimethyl-1H-indol-5-yl)oxy)-2-methyl-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Bromo-2-methylpropanoic acid | HCID 74924 | — |
| 반응물 | 3-(4-chlorophenyl)-1,2-dimethyl-1H-indole-5-ol | HCID 20529164 | — |
| 용매 | Chloroform methanol | HCID 21584188 | — |
| 생성물 | Propanoic acid, 2-((3-(4-chlorophenyl)-1,2-dimethyl-1H-indol-5-yl)oxy)-2-methyl- | HCID 3059432 | — |
반응 단계
A mixture of 5.4 g (0.02 mole) of 3-(4-chlorophenyl)-1,2-dimethyl-1H-indole-5-ol, and 5.1 g (0.03 mole) of 2-bromo-2-methyl-propanoic acid was heated for two hours to 90°-130° C. Subsequently the mixture was taken up in chloroform/methanol (8:2) and chromatographed on silicagel. The evaporation residue of the eluate was stirred with cyclohexane and suction filtered.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04343811 |
| 출처 데이터셋 | uspto-grants-1982_08 |
| ORD ID | ord-ada52e101a4645c99cec87490df7da89 |
| 출처 메모 | uspto-grants-1982_08 |