Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzaldehyde → HCID 20528326, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzaldehyde | HCID 240 | — |
| 반응물 | Potassium Cyanide | HCID 9032 | — |
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | 1,3-Diazepane-2-thione | HCID 736589 | — |
| 반응물 | 2-Thienyl-alpha-hydroxybenzyl ketone | HCID 54002001 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | HCID 20528326 | HCID 20528326 | — |
반응 단계
A mixture of 9.2 ml. of thiophene-2-carboxyaldehyde, 8 g. of potassium cyanide and 10.1 ml. of benzaldehyde in 100 ml. of 65% ethanol is reacted as described in Example 20, giving 6.2 g. of 2-thienyl-α-hydroxybenzyl ketone. A 4.36 g. portion of this ketone is reacted with methanesulfonyl chloride as described in Example 20, giving 3.2 g. of the methanesulfonate ester. A 2.64 g. portion of this ester and 1.30 g. of hexahydro-2H-1,3-diazepine-2-thione in 100 ml. of acetone are allowed to stand 48 hours, the solid is collected, washed with ether and dried in vacuo, giving 2.8 g. of the desired product, m.p. 149°-151° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04344954 |
| 출처 데이터셋 | uspto-grants-1982_08 |
| ORD ID | ord-34472b1a55034bc2a3b0726c4608e611 |
| 출처 메모 | uspto-grants-1982_08 |